Thyroid transcription factor-1(TTF-1), a member of the NKx2 family of homeodomain transcription factors, is expressed in epithelial cells of the thyroid gland and the lung. This antibody is useful for TTF-1 immunohistochemistry to distinguish between lung and nonlung origin of a tumor.

Download datasheet

Catalog Number	WMAB-8G7G31
Quantity	100 µl
Price	$260.00
Category	Monoclonal
Specificity	human & mouse TTF-1, other species not tested
Immunogen	recombinant rat TTF-1 his fusion
Isotype	IgG1/Kappa
Applications & suggested dilutions	Immunoblots - 1:500 Immunohistochemistry - 1:50-1:400 Antigen retrieval: required (see IHC protocol)
Supplied As	Ascites fluid containing 0.01% sodium azide
Storage	Aliquot and store at -20oC. Multiple freeze/thaw cycles not recommended.

References:

Holzinger A, Dingle S, Bejarano PA, Miller MA, Weaver TE, DiLauro R, Whitsett JA. 'Monoclonal antibody to thyroid transcription factor-1: production, characterization, and usefulness in tumor diagnosis'. Hybridoma. 1996 Feb;15(1):49-53.

Stahlman MT, Gray ME, Whitsett JA. 'Expression of thyroid transcription factor-1(TTF-1) in fetal and neonatal human lung.' J Histochem Cytochem. 1996 Jul;44(7):673-8.

Zhou L, Lim L, Costa RH, Whitsett JA. 'Thyroid transcription factor-1, hepatocyte nuclear factor-3beta, surfactant protein B, C, and Clara cell secretory protein in developing mouse lung.' J Histochem Cytochem. 1996 Oct;44(10):1183-93.

Bohinski RJ, Bejarano PA, Balko G, Warnick RE, Whitsett JA. 'Determination of lung as the primary site of cerebral metastatic adenocarcinomas using monoclonal antibody to thyroid transcription factor-1.' J Neurooncol. 1998 Dec;40(3):227-31.